| Identification | Back Directory | [Name]
RO 106-9920 | [CAS]
62645-28-7 | [Synonyms]
RO 106-9920
Ro 106-9920
DISCONTINUED
TETRAZOLOPYRIDAZINE-PHENYLSULFOXIDE
6-(PHENYLSULFINYL)TETRAZOLO[1,5-B]PYRIDAZINE
Tetrazolo[1,5-b]pyridazine, 6-(phenylsulfinyl)- | [Molecular Formula]
C10H7N5OS | [MDL Number]
MFCD06660085 | [MOL File]
62645-28-7.mol | [Molecular Weight]
245.26 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at +4°C | [solubility ]
Soluble to 5 mM in ethanol and to 100 mM in DMSO | [form ]
White solid | [color ]
White to off-white | [InChI]
1S/C10H7N5OS/c16-17(8-4-2-1-3-5-8)10-7-6-9-11-13-14-15(9)12-10/h1-7H | [InChIKey]
JFSXSNSCPNFCDM-UHFFFAOYSA-N | [SMILES]
[S](=O)(c3ccccc3)c1n[n]2nnnc2cc1 |
| Hazard Information | Back Directory | [Uses]
Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Ro 106-9920 blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. | [Definition]
ChEBI: 6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine is a sulfoxide. | [Biological Activity]
Inhibitor of NF- κ B activation, possibly via selective inhibition of LPS- and TNF- α -induced I κ B α ubiquitination (IC 50 = 3 μ M). Blocks subsequent production of TNF- α , IL-1 β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo . Also weakly inhibits EGFR, 5-lipoxygenase and iNOS. |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|