| Identification | Back Directory | [Name]
SD-208 | [CAS]
627536-09-8 | [Synonyms]
SD-208
CS-2295
SCI 208
SD-208 10MG
SD-208 (SD 208
ALK5 Inhibitor V
SD-208 USP/EP/BP
TGF-β RI Kinase Inhibitor V
SD-208;SD 208; SD208; SCI 208
SD 208;SD208;TGF-Β RI KINASE INHIBITOR V
2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine
2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE | [Molecular Formula]
C17H10ClFN6 | [MDL Number]
MFCD09038685 | [MOL File]
627536-09-8.mol | [Molecular Weight]
352.753 |
| Chemical Properties | Back Directory | [Boiling point ]
460.4±45.0 °C(Predicted) | [density ]
1.487 | [storage temp. ]
2-8°C | [solubility ]
DMSO: >5mg/mL | [form ]
powder | [pka]
4.56±0.26(Predicted) | [color ]
off-white to tan | [InChI]
1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25) | [InChIKey]
BERLXWPRSBJFHO-UHFFFAOYSA-N | [SMILES]
Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2 |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Uses]
SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2 | [Biological Activity]
Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity. | [Biochem/physiol Actions]
SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1 | [in vivo]
SD-208 (1 mg/mL, p.o.) significantly prolongs the median survival of SMA-560 glioma-bearing mice[1]. In syngeneic 129S1 mice, SD-208 (60 mg/kg/d, p.o.) inhibits primary R3T tumor growth, and reduces the number and the size of lung metastases[2]. In the murine aortic allograft model, SD-208 effectively reduces the formation of intimal hyperplasia of transplant arteriosclerosis (TA)[3]. | [storage]
Store at RT |
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