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Gerfelin inhibits geranylgeranyl diphosphate synthase (GGPP synthase) activity with an IC50 of 3.5 μg/mL[1]. | [Definition]
ChEBI: Gerfelin is a member of the class of benzoic acids that is salicylic acid which is substituted at position 6 by a methyl group and at position 4 by a 2,3-dihydroxy-5-methylphenoxy group. It has a role as an EC 2.5.1.29 (geranylgeranyl diphosphate synthase) inhibitor and a metabolite. It is a member of benzoic acids, a member of catechols and an aromatic ether. | [References]
[1] Satoko Zenitani, et al. Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities. J Antibiot (Tokyo). 2003 Jul;56(7):617-21. |
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