| Identification | Back Directory | [Name]
5,6BETA-DIHYDRO PGI2 | [CAS]
62770-50-7 | [Synonyms]
6β-Prostaglandin I1
5,6BETA-DIHYDRO PGI2
6BETA-PROSTAGLANDIN I1
5,6-dihydroprostacyclin
RJADQDXZYFCVHV-CBIPHORWSA-N
6S,9ALPHA-EPOXY-11ALPHA,15S-DIHYDROXY-PROST-13E-EN-1-OIC ACID
(6S,13E,15S)-6,9α-Epoxy-11α,15-dihydroxyprost-13-en-1-oic acid
Prost-13-en-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (6S,9α,11α,13E,15S)- (9CI) | [Molecular Formula]
C20H34O5 | [MDL Number]
MFCD00135257 | [MOL File]
62770-50-7.mol | [Molecular Weight]
354.48 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: >10 mg/ml; DMSO: >5 mg/ml; Ethanol: >20 mg/ml; PBS pH 7.2: >80 μg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.1,2 | [Uses]
6β-Prostaglandin I1 (6β-PGI1) is an analog of prostaglandin I2 (PGI2) that is resistant to hydrolysis in aqueous solutions. 6β-Prostaglandin I1 can reduce gastric acid secretion with an ID50 (dose causing 50% inhibition) of approximately 3.0 μg/kg/min (intravenous injection)[1]. | [Definition]
ChEBI: 6-Prostaglandin I1 is a prostanoid. | [References]
1. Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin — a potent stable prostacyclin analogue for the inhibition of platelet aggregation Prostaglandins 19(4),605-627(1980).
2. Blair, I.A., Hensby, C.N., and MacDermot, J. Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationships Br. J. Pharmac. 69(3),519-525(1980). |
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