| Identification | Back Directory | [Name]
PROCATEROL HYDROCHLORIDE | [CAS]
62929-91-3 | [Synonyms]
meptin
opc2009
Epcalol
Cateptin
Astoprotin
PROCATEROL HCL
Einecs 263-763-0
Procaterol hydrochlorid
Procaterol HCl,Procaterol hydrochloride
Procaterol hydrochloride Solution, 100ppm
Procaterol hydrochloride Solution, 1000ppm
8-HYDROXY-5-(1-HYDROXY-2-PROPAN-2-YLAMINO-BUTYL)-1H-QUINOLIN-2-ONE
5-(1-hydroxy-2-isopropylamino)butyl-8-hydroxycarbostyrilhydrochloride
erythro-8-hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]-2(1h)-quinolinone
8-hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1h)-quinolinonmono
(+/-)-ERYTHRO-8-HYDROXY-5-[1-HYDROXY-2-(ISOPROPYLAMINO)BUTYL]CARBOSTYRIL HYDROCHLORIDE
8-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one hydrate hydrochloride
(R*,S*)-(1)-8-Hydroxy-5-(1-hydroxy-2-(isopropylamino)butyl)quinolin-2(1H)-one monohydrochloride
(R*,S*)-(±)-8-hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]quinolin-2(1H)-one monohydrochloride
rel-8-Hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-2(1H)quinolinone hydrochloride
2(1H)-Quinolinone, 8-hydroxy-5-[1-hydroxy-2-[(1-methylethyl)amino]butyl]-, monohydrochloride, (R*,S*)-
2(1H)-Quinolinone, 8-hydroxy-5-[1-hydroxy-2-[(1-methylethyl)amino]butyl]-, monohydrochloride, (R*,S*)-(+-)-
2(1H)-Quinolinone, 8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, monohydrochloride, rel- (9CI) | [EINECS(EC#)]
263-763-0 | [Molecular Formula]
C16H23ClN2O3 | [MDL Number]
MFCD04221378 | [MOL File]
62929-91-3.mol | [Molecular Weight]
326.82 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble to 100 mM in water and to 100 mM in DMSO | [form ]
Powder | [color ]
White to off-white | [Stability:]
Hygroscopic | [InChI]
1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H/t12-,16+;/m0./s1 | [InChIKey]
AEQDBKHAAWUCMT-CVHDTDHSSA-N | [SMILES]
Cl.CC[C@H](NC(C)C)[C@H](O)c1ccc(O)c2NC(=O)C=Cc12 |
| Hazard Information | Back Directory | [Description]
Procaterol is an agonist of β2-adrenergic receptors (β2-ARs).1 It binds to (Kd = 46 pM), and is selective for, β2-ARs over β1-ARs (Kd = 4,000 pM). Procaterol binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (Item No. 16060; IC50s = 55.1 and 1,660 nM, respectively).2 It inhibits contractions induced by acetylcholine (Item No. 23829) in isolated guinea pig trachea (EC50 = 10.5 nM).3 In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 μg/ml.4 | [Uses]
adrenergic agonists | [General Description]
Procaterol is used to prevent lung fibroblast migration. It has anti-inflammatory properties. It can block type 2 T helper (Th2)-related chemokine production in human monocytes and bronchial epithelial cells. | [Biological Activity]
Specific and very potent β 2 agonist. | [Biochem/physiol Actions]
β2-adrenoceptor agonist; bronchodilator. | [storage]
Store at RT | [References]
[1] S MARULLO. Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites.[J]. EMBO Journal, 1990, 9 5: 1471-1476. DOI: 10.1002/j.1460-2075.1990.tb08264.x
[2] HIDEO KIKKAWA Katsuo I Kazuaki Naito. Tracheal Relaxing Effects and β2-Selectivity of TA-2005, a Newly Developed Bronchodilating Agent, in Isolated Guinea Pig Tissues[J]. Japanese journal of pharmacology, 1991, 57 2: Pages 175-185. DOI: 10.1254/jjp.57.175
[3] SHIRO YOSHIZAKI. Sympathomimetic amines having a carbostyril nucleus[J]. Journal of Medicinal Chemistry, 1976, 19 9: 1138-1142. DOI: 10.1021/jm00231a011
[4] MIRZA. Inhaled procaterol inhibits histamine-induced airflow obstruction and microvascular leakage in guinea-pig airways with allergic inflammation[J]. Clinical and Experimental Allergy, 2008, 28 5: 644-652. DOI: 10.1046/j.1365-2222.1998.00263.x |
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| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
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