| Identification | Back Directory | [Name]
L-4-CHLOROPHENYLALANINE METHYL ESTER HCL | [CAS]
63024-26-0 | [Synonyms]
Methyl 4-chloro-L-phenylalaninate
L-4-CHLOROPHENYLALANINE METHYL ESTER HCL
P-CHLOROPHENYLALANINE METHYLESTER HYDROCHLORIDE
METHYL 4-CHLORO-L-PHENYLALANINATE HYDROCHLORIDE
L-3-(2-Naphthyl)alanine methyl ester hydrochloride
β-(2-naphthyl)-L-alanine methyl ester hydrochloride
METHYL (2S)-2-AMINO-3-(4-CHLOROPHENYL)PROPANOATE HCL
beta-(2-Naphthyl)-L-alanine Methyl Ester Hydrochloride
methyl (S)-2-amino-3-(naphthalen-2-yl)propanoate hydrochloride
(S)-Methyl 2-amino-3-(naphthalen-2-yl)propanoate hydrochloride
2-Naphthalenepropanoic acid, a-amino-, methyl ester, hydrochloride,(S)- | [Molecular Formula]
C10H13Cl2NO2 | [MDL Number]
MFCD01317720 | [MOL File]
63024-26-0.mol | [Molecular Weight]
250.12 |
| Chemical Properties | Back Directory | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [Appearance]
White to off-white Solid | [Optical Rotation]
18.6°(C=0.01g/ml ETOH) |
| Hazard Information | Back Directory | [Synthesis]
Step B: Methyl (2S)-2-(tert-butoxycarbonylamino)-3-(naphthalen-2-yl)propionate (5.52 g, 15.85 mmol) and 20 mL of ethyl acetate were added to a 500 mL round-bottom flask fitted with a magnetic stirrer. 80 mL of 2.8 M hydrogen chloride in ethyl acetate solution was slowly added under stirring and the reaction was carried out under nitrogen protection for 2.5 hours. Upon completion of the reaction, the reaction mixture was concentrated to dryness under reduced pressure to give the crude product. The crude product was dissolved in an appropriate amount of ethyl acetate, stirred for 10 minutes and filtered to collect the solid. The resulting solid was dried under vacuum at 40 °C to give (2S)-2-amino-3-(naphthalen-2-yl)propanoic acid methyl ester hydrochloride 3.91 g in 93% yield as a white solid.HPLC-MS analysis: retention time (Rt) = 3.70 min, molecular ion peak (M + 1) = 230, % ELS area = 100%. | [References]
[1] Patent: US2007/185128, 2007, A1. Location in patent: Page/Page column 27 |
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