| Identification | Back Directory | [Name]
ANDROSTA-1,4,6-TRIENE-3,17-DIONE | [CAS]
633-35-2 | [Synonyms]
Δ1,4,6-androgen
1,4,6-Andorstatriene-3,17-dione
androsta-1,4,6-triene-3,17-dione
1,4,6-Androstatriene-3,17-dione(ATD)
Androsta-1,4,6-triene-3,17-dione (1.0mg/mL in MeOH) | [EINECS(EC#)]
1806241-263-5 | [Molecular Formula]
C19H22O2 | [MOL File]
633-35-2.mol | [Molecular Weight]
282.38 |
| Chemical Properties | Back Directory | [Melting point ]
164-1650C | [Boiling point ]
452.8±45.0 °C(Predicted) | [density ]
1.16±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
methanol: 50 mg/mL, soluble
| [form ]
powder
|
| Hazard Information | Back Directory | [Chemical Properties]
Brownish Yellow Solid | [Uses]
A solution of Androsta-1,4,6-triene-3,17-dione which is selective receptor modulator inhibitor. | [Definition]
ChEBI: An androstanoid that is androsta-1,4,6-triene substituted by oxo groups at positions 3 and 17. | [in vivo]
Androsta-1,4,6-triene-3,17-dione (25-100 mg/kg; s.c.) prevents the normal rise in ovarian estradiol concentrations[2].
Androsta-1,4,6-triene-3,17-dione may act in vivo to inhibit fertility by inhibition of estrogen biosynthesis [1].
| Animal Model: | Rats (220-250 g)[2] | | Dosage: | 25 mg/kg, 100 mg/kg | | Administration: | Subcutaneous injection | | Result: | Prevented the normal rise in ovarian estradiol concentrations with a single injection 3 hours before the time of the estrogen surge on proestrus. |
| [IC 50]
Aromatase |
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