| Identification | Back Directory | [Name]
5,5-DIPHENYLHYDANTOIN-D5 98 ATOM % D | [CAS]
63435-68-7 | [Synonyms]
phenytoin-d5
5,5-Diphenylhydantoin-d5
5,5-DIPHENYLHYDANTOIN-D5 98 ATOM % D
5-((Phenyl-D5)-5-Phenylhydantoin (98% D5)
5-Phenyl-5-(phenyl-d5)-2,4-imidazolidinedione | [Molecular Formula]
C15H11DN2O2 | [MDL Number]
MFCD00069673 | [MOL File]
63435-68-7.mol | [Molecular Weight]
253.274 |
| Hazard Information | Back Directory | [Uses]
5-Phenyl-5-(phenyl-d5)imidazolidine-2,4-dione is deuterium-labeled 5-Phenyl-5-(phenyl-d5)imidazolidine-2,4-dione[1]. | [in vivo]
Isotopic labels can non-invasively track the distribution, transformation and clearance of compounds and their metabolites in the body through techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR), which is beneficial to the study of pharmacometabolic kinetics (ADME).
Isotope labeling can reveal specific steps in metabolic pathways. Using compounds with stable isotope labels at specific locations directly in humans or animal models can also help verify drug mechanisms and evaluate unexpected side effects, improving the accuracy and efficiency of clinical research[3]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Smith K A, et al. Soil and environmental analysis[M]. Marcel Dekker Incorporated, 2000.
[3] Fan T W M, et al. Stable isotope-resolved metabolomics and applications for drug development[J]. Pharmacology & therapeutics, 2012, 133(3): 366-391. DOI:10.1016/j.pharmthera.2011.12.007 |
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