| Identification | Back Directory | [Name]
Censavudine | [CAS]
634907-30-5 | [Synonyms]
4'-Ed4T
BMS 986001
Festinavir
Censavudine
2',3'-Didehydro-3'-deoxy-4'-ethynylthymidine
Thymidine, 2',3'-didehydro-3'-deoxy-4'-ethynyl- | [Molecular Formula]
C12H12N2O4 | [MDL Number]
MFCD28502139 | [MOL File]
634907-30-5.mol | [Molecular Weight]
248.23 |
| Chemical Properties | Back Directory | [Melting point ]
207-209℃ | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture | [solubility ]
DMSO : 52 mg/mL (209.48 mM; Need ultrasonic) | [form ]
Solid | [pka]
9.47±0.10(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C12H12N2O4/c1-3-12(7-15)5-4-9(18-12)14-6-8(2)10(16)13-11(14)17/h1,4-6,9,15H,7H2,2H3,(H,13,16,17)/t9-,12+/m1/s1 | [InChIKey]
OSYWBJSVKUFFSU-SKDRFNHKSA-N | [SMILES]
OC[C@@]1(C#C)O[C@@H](N2C=C(C)C(=O)NC2=O)C=C1 |
| Hazard Information | Back Directory | [Uses]
Festinavir is a modified nucleoside which has been shown great in vitro activity against HIV-2. It has also been used as potent inhibitor against entecavir-resistant hepatitis B. | [in vivo]
The pharmacokinetic parameters of Censavudine (BMS-986001; 100-750 mg/kg) generated from the dried blood spot (DBS) assay and the plasma assay is compared. The ratios of the AUC(0-24 h) and C max for BMS-986001 in DBS compared to those in plasma are consistent at 0.83-0.91 and 0.81-0.97, respectively, across all dose groups in rats. The T max in rat DBS and plasma are also consistent at about 1 h[2]. | [IC 50]
HIV-2: 30-81 nM (EC50); HIV-1: 450-890 nM (IC50) |
|
| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
NewCan Biotech Limited
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| Tel: |
+86-0571-86912261 +86-15658003402 |
| Website: |
https://www.newcanbio.com/ |
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