| Identification | Back Directory | [Name]
3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester | [CAS]
634911-80-1 | [Synonyms]
Caspase Inhibitor Boc-D-FMK
Caspase3-Inhibitor Boc-D-FMK
1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-
3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester
Pentanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-5-fluoro-4-oxo-, Methyl ester
BOC-D-FMK
(Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester) | [Molecular Formula]
C11H18FNO5 | [MDL Number]
MFCD03453073 | [MOL File]
634911-80-1.mol | [Molecular Weight]
263.26 |
| Chemical Properties | Back Directory | [Boiling point ]
383.5±37.0 °C(Predicted) | [density ]
1.150 | [storage temp. ]
-20°C | [solubility ]
DMSO: 5mg/mL | [form ]
<31.2°C Solid,>31.2°C Liquid | [pka]
10.12±0.46(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16) | [InChIKey]
MXOOUCRHWJYCAL-UHFFFAOYSA-N | [SMILES]
C(OC)(=O)CC(NC(OC(C)(C)C)=O)C(=O)CF |
| Hazard Information | Back Directory | [Uses]
Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC50 of 39 μM. | [Biological Activity]
Cell permeable: yes''Primary Target
broad spectrum caspase''Product does not compete with ATP.''Reversible: no | [in vivo]
Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge[3]. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle[4]. | [IC 50]
Caspase | [References]
[1] Cowburn AS, et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. DOI:10.1182/blood-2004-07-2870
[2] Yee SB, et al. zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells. Exp Mol Med. 2006 Dec 31;38(6):634-42. DOI:10.1038/emm.2006.75
[3] Sheen-Chen SM, et al. Effect of Boc-D-Fmk on hepatocyte apoptosis after bile duct ligation in rat and survival rate after endotoxin challenge. J Gastroenterol Hepatol. 2008 Aug;23(8 Pt 1):1276-9. DOI:10.1111/j.1440-1746.2008.05368.x
[4] Chan YM, et al. Inhibition of caspases promotes long-term survival and reinnervation by axotomized spinal motoneurons of denervated muscle in newborn rats. Exp Neurol. 2003 Jun;181(2):190-203. DOI:10.1016/s0014-4886(03)00023-2 |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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