| Identification | Back Directory | [Name]
1,2,4,5-tetrahydroxybenzene | [CAS]
636-32-8 | [Synonyms]
1,2,4,5-Benzenetetrol
benzene-1,2,4,5-tetrol
Benzene-1,2,4,5-tetraol
1,2,4,5-tetrahydroxybenzene
benzene-1，2，4，5-tetrol,≥98%
Phloroglucinol Impurity 206
5-Hydroxybenzene-1,2,4-triol | [Molecular Formula]
C6H6O4 | [MOL File]
636-32-8.mol | [Molecular Weight]
142.11 |
| Chemical Properties | Back Directory | [Melting point ]
210 °C | [Boiling point ]
477.1±40.0 °C(Predicted) | [density ]
1.709±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
9.72±0.23(Predicted) | [Appearance]
Gray to brown Solid | [CAS DataBase Reference]
636-32-8 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 1,2,4,5-benzenetetrol from 2,5-dihydroxy-1,4-benzoquinone: To a solution of 2,5-dihydroxy-1,4-benzoquinone (2.0 g, 1.0 eq.) in hydrochloric acid (110 mL) was slowly added tin particles (2.068 g, 1.2 eq.). The reaction mixture was heated to 110 °C and maintained for 1 hour. When the temperature of the reaction solution was reduced to 50-60 °C, thermal filtration was carried out and the filtrate was subsequently cooled to 0 °C to promote crystallization, resulting in colorless crystals of 1,2,4,5-benzenetetrol (1.450 g, 74%). The product was characterized by 1H NMR (MeOD, 300 MHz): δ 5.0 (broad peak, 4H), 5.90 (single peak, 2H).ESI-MS showed molecular ion peak m/z 145.03 [M+]. | [References]
[1] Journal of Organometallic Chemistry, 2000, vol. 614-615, p. 188 - 194
[2] Journal of Organic Chemistry, 2008, vol. 73, # 12, p. 4452 - 4457
[3] Chemistry - A European Journal, 2013, vol. 19, # 51, p. 17349 - 17357
[4] European Journal of Medicinal Chemistry, 2013, vol. 67, p. 269 - 279
[5] Collection of Czechoslovak Chemical Communications, 2012, vol. 77, # 3, p. 201 - 209 |
|
|