| Identification | Back Directory | [Name]
GAMMA-GLU-CYS TRIFLUOROACETATE SALT | [CAS]
636-58-8 | [Synonyms]
γ-glu-cys
y-Glu-Cys
gaMMa-Glu-Cys
H-g-Glu-Cys-OH
Gamma Glu-L-Cys-OH
H-GLU(CYS-OH)-OH TFA
gamma-glutamylcysteine
γ-L-Glutamyl-L-cysteine
5-L-Glutamyl-L-cysteine
Glutathione Ep Impurity D
G-glu-cys trifluoroacetate
gamma-L-Glutamyl-L-cysteine
L-gamma-Glutamyl-L-cysteine
des-gly-glutathione reduced form
GAMMA-GLU-CYS TRIFLUOROACETATE SALT
(DES-GLY)-GLUTATHIONE TFA (REDUCED)
GAMMA-GLU-CYS TRIFLUOROACETATE SALT USP/EP/BP
Glutathione Impurity 11（Glutathione EP Impurity D）
γ-L-Glutamyl-L-cysteine, des-Gly-glutathione reduced form
2-amino-5-(1-carboxy-2-sulfanyl-ethyl)amino-5-oxo-pentanoic acid
γ-Glu-Cys,γ-L-Glutamyl-L-cysteine, des-Gly-glutathione reduced form
(S)-2-amino-5-(((R)-1-carboxy-2-mercaptoethyl)amino)-5-oxopentanoic acid
(2S)-2-amino-5-[[(2R)-1-hydroxy-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
(2S)-2-azanyl-5-[[(2R)-1-hydroxy-1-oxo-3-sulfanyl-propan-2-yl]amino]-5-oxo-pentanoic acid
(2S)-2-amino-5-[[(1R)-2-hydroxy-2-keto-1-(mercaptomethyl)ethyl]amino]-5-keto-valeric acid
(S)-2-amino-5-(((R)-1-carboxy-2-mercaptoethyl)amino)-5-oxopentanoic acid compound with 2,2,2-trifluoroacetic acid (1:1) | [Molecular Formula]
C8H14N2O5S | [MDL Number]
MFCD00133357 | [MOL File]
636-58-8.mol | [Molecular Weight]
250.27 |
| Questions And Answer | Back Directory | [Description]
Gamma-glutamylcysteine (γ-Glutamylcysteine) is a cysteine and glutamic acid-containing dipeptide that is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels. |
| Chemical Properties | Back Directory | [Melting point ]
167℃ | [Boiling point ]
592.4±50.0 °C(Predicted) | [density ]
1.436±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
≥ 25mg/mL in Water, ≥ 52 mg/mL in DMSO, ≥ 54.8 mg/mL in EtOH | [form ]
Solid | [pka]
2.21±0.10(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C8H14N2O5S/c9-4(7(12)13)1-2-6(11)10-5(3-16)8(14)15/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 | [InChIKey]
RITKHVBHSGLULN-WHFBIAKZSA-N | [SMILES]
C(O)(=O)[C@@H](N)CCC(N[C@H](C(O)=O)CS)=O |
| Hazard Information | Back Directory | [Uses]
γ-Glu-Cys is used to study the active sites and kinetics of glutathione synthetase(s). It has also been used for the extraction and quantification of low molecular weight thiols from Arabidopsis tissues. | [Definition]
ChEBI: A molecular entity formed when L-cysteine amino group binds to the gamma-carbonyl of L-glutamic acid. | [Biochem/physiol Actions]
γ-L-Glutamyl-L-cysteine (γ-Glu-Cys) is a substrate used for the biosynthesis of L-glutathione by glutathione synthetase(s). γ-Glu-Cys is generated by the cleavage of the Cys-Gly peptide bond of glutathione. It is also essential for the formation of phytochelatins, which are cysteine-rich thiol-reactive peptides. | [IC 50]
Human Endogenous Metabolite | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
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| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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