| Identification | Back Directory | [Name]
[1-(2,5-dimethylbenzyl)-1H-benzimidazol-2-yl]methanol | [CAS]
637324-45-9 | [Synonyms]
[1-(2,5-dimethylbenzyl)-1H-benzimidazol-2-yl]methanol
1H-Benzimidazole-2-methanol, 1-[(2,5-dimethylphenyl)methyl]- | [Molecular Formula]
C17H18N2O | [MOL File]
637324-45-9.mol | [Molecular Weight]
266.34 |
| Hazard Information | Back Directory | [Description]
UCB-6876 is a novel inhibitor of TNF signalling by stabilising an asymmetric form of the trimer, displaying a concentration-dependent response curve and selectivity over the TNFR1 extracellular domain and control proteins. | [Uses]
UCB-6876 is a TNFα inhibitor and binds to asymmetrical crystal form of the TNF trimer (KD?=?22 μM)[1][2]. | [References]
[1] Eguida M, et al. Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. J Cheminform. 2021 Nov 23;13(1):90. DOI:10.1186/s13321-021-00567-3
[2] O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10(1):5795. DOI:10.1038/s41467-019-13616-1 |
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| Company Name: |
OTAVA chemicals
|
| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
| Company Name: |
Specs
|
| Tel: |
+31 15 251 8111 |
| Website: |
www.specs.net |
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