| Identification | Back Directory | [Name]
Cyclosporin B | [CAS]
63775-95-1 | [Synonyms]
CYCLOSPORIN B
Ala2-cyclosporine
Antibiotic S 7481F2
Cyclosporin B (9CI)
Cyclosporin B, >=95%
Cyclosporine IMpurity-B
7-L-Alaninecyclosporine A
(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Ala-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alanyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl] | [Molecular Formula]
C61H109N11O12 | [MDL Number]
MFCD08062361 | [MOL File]
63775-95-1.mol | [Molecular Weight]
1188.58 |
| Chemical Properties | Back Directory | [Appearance]
Amorphous White Solid | [Melting point ]
149-152°C | [alpha ]
D20 -238° (c = 0.62 in chloroform); D20 -168° (c = 0.56 in methanol) | [Boiling point ]
1289.7±65.0 °C(Predicted) | [density ]
1.019±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.32±0.70(Predicted) | [color ]
White to Pale Yellow | [InChIKey]
UCOQITKXMNKTKF-MHWLBTFJNA-N |
| Hazard Information | Back Directory | [Chemical Properties]
Amorphous White Solid | [Uses]
An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.
A group of nonpolar cyclic oligopeptides with immunosupppressant activity. | [Uses]
Cyclosporin B is a minor analogue of the cyclosporin complex produced by a number of different fungal genera including Trichoderma, Tolypocladium, Fusarium, Nectria and Acremonium. Cyclosporin B possesses immunosuppressant and antifungal activities but has been much less extensively investigated than the major analogue, cyclosporin A. |
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