| Identification | Back Directory | [Name]
Cyclosporine | [CAS]
63798-73-2 | [Synonyms]
Cyclosporin A, 5-L-valine-
(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-L-Val-) | [Molecular Formula]
C61H109N11O12 | [MDL Number]
MFCD09838898 | [MOL File]
63798-73-2.mol | [Molecular Weight]
1188.61 |
| Hazard Information | Back Directory | [Uses]
Cyclosporin E (11-Demethylcyclosporin A) is a cyclic oligopeptide that can be isolated from fungi such as TTrichoderma polysporum and other imperfect fungi. Cyclosporin E belongs to the Cyclosporins family. Cyclosporin E can be used for studying the structure-activity relationships and molecular dynamic properties of cyclosporin compounds. As a structural control compound, Cyclosporin E holds significant research value in the fields of medicinal chemistry and biophysics[1][2]. | [References]
[1] Traber R, et al. Neue Cyclopeptide aus Trichoderma polysporum (LINK EX PERS.) RIFAI: die Cyclosporine B, D und E [New cyclopeptides from Trichoderma polysporum (Link ex Pers.) Rifai: cyclosporins B, D and E (author's transl)]. Helv Chim Acta. 1977;60(5):1568-78. German. DOI:10.1002/hlca.19770600513
[2] Kobchikova P P, et al. Features of spatial structures of cyclosporins D, E and G revealed by NMR and MD simulations[J]. Journal of Molecular Liquids, 2021, 336: 116244. |
|
|