| Identification | Back Directory | [Name]
5-BROMO-4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE | [CAS]
63810-78-6 | [Synonyms]
5-Bromo-4-chloro-2-(methy...
5-Bromo-4-chloro-2-(methylthio)pyrimidine
Pyrimidine, 5-bromo-4-chloro-2-(methylthio)-
5-BROMO-4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE
5-Bromo-4-chloro-2-(methylthio)pyrimidine >
5-Bromo-4-chloro-2-(methylthio)pyrimidine ,97%
5-BROMO-4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE ISO 9001：2015 REACH | [Molecular Formula]
C5H4BrClN2S | [MDL Number]
MFCD00023232 | [MOL File]
63810-78-6.mol | [Molecular Weight]
239.521 |
| Chemical Properties | Back Directory | [Melting point ]
45.0 to 49.0 °C | [Boiling point ]
309.5±22.0 °C(Predicted) | [density ]
1.83±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
-1.97±0.29(Predicted) | [color ]
White to Almost white | [InChI]
InChI=1S/C5H4BrClN2S/c1-10-5-8-2-3(6)4(7)9-5/h2H,1H3 | [InChIKey]
XVRYJQACDDVZEI-UHFFFAOYSA-N | [SMILES]
C1(SC)=NC=C(Br)C(Cl)=N1 | [CAS DataBase Reference]
63810-78-6 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Synthesis]
Step 3, Preparation of 5-bromo-4-chloro-2-methylthiopyrimidine: 5-bromo-2-(methylthio)pyrimidin-4(3H)-one (110 g) was dissolved in pyridine (400 g) and heated to 80°C. Phosphorus trichloride (100 g) was added dropwise with stirring. After the dropwise addition, the reaction temperature was maintained and stirring was continued for 5 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and subsequently placed in an ice bath. The pH was adjusted to 8-9 with saturated sodium bicarbonate solution and then extracted with ethyl acetate (500 mL). The organic phase was dried with anhydrous magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure to remove the solvent. The residue was recrystallized by a solvent mixture of petroleum ether and ethyl acetate (1:3, v/v) to give a pale yellow solid powder (98 g) in 83% yield. | [References]
[1] Patent: CN107488175, 2017, A. Location in patent: Paragraph 0008; 0010
[2] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1982, vol. 36, # 1 B, p. 15 - 18 |
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