| Identification | Back Directory | [Name]
benzothiophene-6-carbaldehyde | [CAS]
6386-80-7 | [Synonyms]
benzothiophene-6-carbaldehyde
1-Benzothiophene-6-carbaldehyde
Benzo[b]thiophene-6-carbaldehyde
1-Benzothiophene-6-carboxaldehyde
Benzo[b]thiophene-6-carboxaldehyde | [Molecular Formula]
C9H6OS | [MDL Number]
MFCD18451824 | [MOL File]
6386-80-7.mol | [Molecular Weight]
162.21 |
| Chemical Properties | Back Directory | [Melting point ]
42.0-42.5 °C | [Boiling point ]
303.2±15.0 °C(Predicted) | [density ]
1.300±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [Appearance]
White to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Magnesium shavings (257 mg, 10.6 mmol) were suspended in anhydrous tetrahydrofuran (THF, 1.7 mL) in a 25 mL three-neck flask and heated to reflux. A solution of 6-bromobenzo[b]thiophene (1.5 g, 7.04 mmol) in anhydrous THF (8.3 mL) was added slowly and dropwise. The reaction mixture was refluxed for 2 h and then cooled to 0°C. Subsequently, N,N-dimethylformamide (1.03 g, 1.09 mL, 14.1 mmol) was slowly added dropwise and the reaction system was allowed to warm up to room temperature naturally. The resulting green suspension was stirred overnight and concentrated. The residue was purified by silica gel column chromatography. The target fraction was collected and dried under vacuum to give benzo[b]thiophene-6-carbaldehyde (821 mg, 72% yield) as a yellow oil. | [References]
[1] Patent: WO2014/86663, 2014, A1. Location in patent: Page/Page column 61 |
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| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|