| Hazard Information | Back Directory | [Description]
KSP-IA is a potent, specific, allosteric and cell-active inhibitor of KSP. | [Uses]
KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC50 value of 3.6 nM. KSP-IA inhibits cell mitosis[1]. | [References]
[1] Fraley ME, et, al. Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1775-9. DOI:10.1016/j.bmcl.2006.01.030 |
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