| Identification | Back Directory | [Name]
4-CHLORO-5-METHOXYPYRIDAZIN-3(2H)-ONE | [CAS]
63910-43-0 | [Synonyms]
AURORA KA-6685
5-chloro-4-methoxy-1H-pyridazin-6-one
4-CHLORO-5-METHOXYPYRIDAZIN-3(2H)-ONE
3(2H)-Pyridazinone, 4-chloro-5-methoxy-
4-Chloro-5-methoxy-3(2H)-pyridazinone
4-chloro-5-methoxy-2,3-dihydropyridazin-3-one
4-Chloro-2,3-dihydro-5-methoxy-3-oxopyridazine
4-CHLORO-5-METHOXYPYRIDAZIN-3(2H)-ONE ISO 9001：2015 REACH | [Molecular Formula]
C5H5ClN2O2 | [MDL Number]
MFCD04971392 | [MOL File]
63910-43-0.mol | [Molecular Weight]
160.56 |
| Chemical Properties | Back Directory | [Melting point ]
225 °C(dec.) | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
powder to crystal | [pka]
8.90±0.60(Predicted) | [color ]
White to Orange to Green |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-chloro-5-methoxypyridazin-3(2H)-one (10): to a solution of 4,5-dichloropyridazin-3(2H)-one (4.1 g, 24.8 mmol) in methanol (50 mL) was added sodium methanolate (2.6 g, 74.5 mmol). The reaction mixture was stirred at 80 °C overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure and purified by column chromatography [eluent: petroleum ether to petroleum ether/dichloromethane/methanol (10:1:1)] to afford the target product, 4-chloro-5-methoxypyridazin-3(2H)-one (10) (1.2 g, 30% yield), as a white solid. The procedure for the synthesis of 4-chloro-2-(2-chlorobenzyl)-5-methoxypyridazin-3(2H)-one (11) was not provided with complete information. | [References]
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 19, p. 4716 - 4730
[2] Patent: WO2015/143164, 2015, A1. Location in patent: Page/Page column 115
[3] Monatshefte fuer Chemie, 1989, vol. 120, p. 329 - 342 |
|
|