| Identification | Back Directory | [Name]
5-bromo-5'-phenyl-1-(2-phenylethyl)-1,2',3,3'-tetrahydrospiro(2H-indole-3,2'-[1,3,4]-thiadiazole)-2-one | [CAS]
639507-03-2 | [Synonyms]
CFM5
CFM-5
CFM 5
5-bromo-5'-phenyl-1-(2-phenylethyl)-1,2',3,3'-tetrahydrospiro(2H-indole-3,2'-[1,3,4]-thiadiazole)-2-one | [Molecular Formula]
C23H18BrN3OS | [MOL File]
639507-03-2.mol | [Molecular Weight]
464.378 |
| Hazard Information | Back Directory | [Description]
CFM-5 is an antagonist of anaphase-promoting complex (APC)-2 and cell cycle and apoptosis regulatory protein (CARP)-1 interaction. | [Uses]
CFM-5 inhibits CARP-1/CCAR1-APC-2 interaction with an IC50 value of 0.75 μM. CFM-5 inhibits medulloblastoma (MB) cell proliferation and induces apoptosis[1][2]. | [References]
[1] Abdelkader E Ashour, et al. CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS One. 2013 Jun 24;8(6):e66733. DOI:10.1371/journal.pone.0066733
[2] Magesh Muthu, et al. CARP-1/CCAR1: a biphasic regulator of cancer cell growth and apoptosis. Oncotarget. 2015 Mar 30;6(9):6499-510. DOI:10.18632/oncotarget.3376 |
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