| Identification | Back Directory | [Name]
Valopicitabine dihydrochloride | [CAS]
640725-71-9 | [Synonyms]
NMC283
NMC-283
Valopicitabine HCl
Valopicitabine dihydrochloride
Valopicitabine dihydrochloride, Valopicitabine HCl | [Molecular Formula]
C15H24N4O6.2HCl | [MDL Number]
MFCD34589916 | [MOL File]
640725-71-9.mol | [Molecular Weight]
392.84 |
| Chemical Properties | Back Directory | [Melting point ]
210 °C | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination[1][2]. | [in vivo]
Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) dihydrochloride shows the Cmax, AUC, t1/2, and tmax were 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively[2]. | [References]
[1] Liu-Young G, et al. Hepatitis C protease and polymerase inhibitors in development. AIDS Patient Care STDS. 2008;22(6):449-457. DOI:10.1089/apc.2007.0199
[2] Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem. 2006;49(22):6614-6620. DOI:10.1021/jm0603623 |
|
|