ChemicalBook--->CAS DataBase List--->642-18-2

642-18-2

642-18-2 Structure

642-18-2 Structure
IdentificationBack Directory
[Name]

Indole alkaloid
[CAS]

642-18-2
[Synonyms]

Aids002662
Aids-002662
3,4,5,6,16,17-Hexadehydro-16-(methoxycarbonyl)-19.alpha.-methyl-20.alpha.- oxayohimbanium
Oxayohimbanium,3,4,5,6,16,17-hexadehydro-16-(methoxycarbonyl)-19-methyl-, inner salt, (19a,20a)-
[Molecular Formula]

C21H20N2O3
[MDL Number]

MFCD00083501
[MOL File]

642-18-2.mol
[Molecular Weight]

348.4
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

White to yellow
Hazard InformationBack Directory
[Definition]

ChEBI: Alstonine is an indole alkaloid with formula C21H20N2O3, isolated from several Rauvolfia species and exhibits antipsychotic activity. It has a role as an antipsychotic agent. It is a methyl ester, an organic heteropentacyclic compound, a zwitterion and an indole alkaloid. It is a conjugate base of an alstonine(1+).
[Biological Activity]

Alstonine is the main indole alkaloid compound of a botanical drug. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties.
[in vitro]

Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues.

[in vivo]

In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (ip) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg.
Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages.
Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells.

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