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642008-81-9

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642008-81-9 Structure

642008-81-9 Structure
IdentificationBack Directory
[Name]

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
[CAS]

642008-81-9
[Synonyms]

BRD6989
BRD6989 (BRD-6989
BRD6989 >=98% (HPLC)
2-Amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile
2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
[Molecular Formula]

C16H16N4
[MDL Number]

MFCD04013193
[MOL File]

642008-81-9.mol
[Molecular Weight]

264.33
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

Soluble in DMSO
[form ]

powder
[color ]

white to beige
[InChI]

1S/C16H16N4/c1-10-4-5-14-12(7-10)15(11-3-2-6-19-9-11)13(8-17)16(18)20-14/h2-3,6,9-10H,4-5,7H2,1H3,(H2,18,20)
[InChIKey]

QSYBDNXNOJIKML-UHFFFAOYSA-N
[SMILES]

NC1=NC(CCC(C)C2)=C2C(C3=CN=CC=C3)=C1C#N
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

BRD 6989, is a small molecule inhibitor with high selectivity for CDK8 over CDK19. Increases IL-10 production in stimulated human and murine macrophages and dendritic cells.
[Definition]

ChEBI: 2-amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile is a member of bipyridines.
[Biological Activity]

BRD6989 is an inhibitor of cyclin-dependent kinase 8 (CDK8) th at upregulates production of interleukin-10 (IL-10). BRD6989 was shown to bind cyclin C–CDK8 complex selectively with an IC50 value ∼200 nM and to inhibit the kinase activity of recombinant cyclin C–CDK8 or cyclin C–CDK19 complexes with IC50 values ∼500 nM and >30 μMrespectively. It enhanced the production interleukin-10 (IL-10) enhances IL-10 production in activated human and murine macrophages and dendritic cells with an EC50 value ∼1 μM.
[IC 50]

CDK8: ~200 nM (IC50); recombinant CDK8: ~0.5 μM (IC50); recombinant CDK19: >30 μM (IC50); IL-10
[storage]

Store at +4°C
Spectrum DetailBack Directory
[Spectrum Detail]

2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile(642008-81-9)1HNMR
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