| Identification | Back Directory | [Name]
Methyl 2-aMino-6-hydroxybenzoate | [CAS]
64241-01-6 | [Synonyms]
Prucalopride Impurity45
Methyl 2-aMino-6-hydroxybenzoate
Prucalopride Succinate iMpurit 45
2-AMino-6-hydroxy-benzoic acid Methyl ester
Benzoic acid, 2-amino-6-hydroxy-, methyl ester
methyl 2-2-amino-6-6-hydroxybenzoate - [AC78555] | [Molecular Formula]
C8H9NO3 | [MDL Number]
MFCD20693627 | [MOL File]
64241-01-6.mol | [Molecular Weight]
167.16 |
| Chemical Properties | Back Directory | [Melting point ]
147-148 °C | [Boiling point ]
278.3±20.0 °C(Predicted) | [density ]
1.305±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
9.81±0.10(Predicted) | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for synthesizing methyl 2-amino-6-hydroxybenzoate from indirubic anhydride is as follows:Example 386B Synthesis of methyl 2-amino-6-hydroxybenzoate. Example 386A (1.0 g, 5.6 mmol) was mixed with methanol (40 mL) and heated to reflux for 6 hours. Upon completion of the reaction, the mixture was concentrated and purified by silica gel column chromatography using a hexane solution of 30% ethyl acetate as eluent to give 0.81 g of the target product, methyl 2-amino-6-hydroxybenzoate, in 86.6% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 3.88 (s, 3H), 5.95 (d, 1H), 6.20 (d, 1H), 6.34 (s, 1H), 7.02 (t, 1H), 10.88 (s, 1H); the mass spectrum (DCI/NH3) showed m/e 168 (M + H)+. | [References]
[1] Patent: US2004/167128, 2004, A1. Location in patent: Page 76 |
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