| Identification | Back Directory | [Name]
(3R,5S,10S,13S,17S)-4,4,10,13-tetramethyl-17-[(2R)-6-methylhept-5-en-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol | [CAS]
64284-64-6 | [Synonyms]
FF-MAS
4,4-Dimethylcholesta-8,14,24-trienol
Follicular Fluid Meiosis-activating Sterol
4,4-DiMethyl-5α-cholesta-8,14,24-trien-3β-ol
"(3β,5a)-4,4-Dimethylcholesta-8,14,24-trien-3-ol"
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
Cholesta-8,14,24-trien-3-ol, 4,4-dimethyl-, (3β,5α)-
(3β,5α)-4,4-DiMethylcholesta-8,14,24-trien-3-ol
(Contain up to 15% 25 isoMer)
(3β,5α)-4,4-Dimethylcholesta-8,14,24-trien-3-ol (Contain up to 15% ?25 isomer)
(3R,5S,10S,13S,17S)-4,4,10,13-tetramethyl-17-[(2R)-6-methylhept-5-en-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol | [Molecular Formula]
C29H46O | [MDL Number]
MFCD00945031 | [MOL File]
64284-64-6.mol | [Molecular Weight]
410.67 |
| Chemical Properties | Back Directory | [Melting point ]
120 - 122°C | [Boiling point ]
512.6±49.0 °C(Predicted) | [density ]
1.00±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
15.15±0.70(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
(3β,5α)-4,4-Dimethylcholesta-8,14,24-trien-3-ol is a follicular fluid meiosis-activating sterol (FF-MAS); a factor present in the pre-ovulatory follicle during the time of oocyte maturation. (3β,5α)-4,4-Dimethylcholesta-8,14,24-trien-3-ol has been shown to protect young oocytes from precocious chromatid separation as well as protecting aged oocytes from predivision during maturation. | [Definition]
ChEBI: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol is a 3beta-sterol and a Delta(14) steroid. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It derives from a hydride of a 5alpha-cholestane. | [Biological Activity]
14-demethyl-14-dehydrolanosterol (FF-MAS) was first identified in follicular fluid of women and plays a key role in oocyte nuclear maturation. The levels of FF-MAS may be regulated by cytochrome P450 family 27 subfamily A member 1. Supplementation of FF-MAS to oocytes promotes meiotic maturation favoring preimplantation. HoweverFF-MAS has low solubility and is metabolized to cholesterol rapidly. |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|