| Identification | Back Directory | [Name]
AMITRIPTYLINE METABOLITE (+/-)- | [CAS]
64520-05-4 | [Synonyms]
10-Hydroxy (E)-Amitriptyline
AMITRIPTYLINE METABOLITE (+/-)-
AMITRIPTYLINE METABOLITE (+-)-(E)-10-HYD ROXYLA
Amitriptyline metabolite, (±)-E-10-hydroxylated-
(E)-5-(3-(Dimethylamino)propylidene)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-ol
5H-Dibenzo[a,d]cyclohepten-10-ol, 5-[3-(dimethylamino)propylidene]-10,11-dihydro-, (5E)-
(11E)-11-[3-(dimethylamino)propylidene]-5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-5-ol | [Molecular Formula]
C20H23NO | [MDL Number]
MFCD00069200 | [MOL File]
64520-05-4.mol | [Molecular Weight]
293.4 |
| Chemical Properties | Back Directory | [Melting point ]
97-99 °C | [Boiling point ]
453.3±45.0 °C(Predicted) | [density ]
1.151±0.06 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
0.1 M HCl: soluble | [form ]
solid | [pka]
13.89±0.20(Predicted) | [color ]
white | [Stability:]
Hygroscopic | [InChI]
1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+ | [InChIKey]
GHWBJXOKAFHZAI-SFQUDFHCSA-N | [SMILES]
CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13 | [EPA Substance Registry System]
5H-Dibenzo[a,d]cyclohepten-10-ol, 5-[3-(dimethylamino)propylidene]-10,11-dihydro-, (5E)- (64520-05-4) |
| Hazard Information | Back Directory | [Uses]
(5E)-5-[3-(dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol is a metabolite of amitriptyline (A633350) which is a dibenzocycloheptadiene derivative and an antidepressant (1). Amitriptyline is also a TrkA and TrkB receptor agonist and exhibits neurotrophic and anti-inflammatory activities (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). | [Definition]
ChEBI: E-10-Hydroxyamitriptyline is an organic tricyclic compound. | [Biochem/physiol Actions]
Metabolite of amitriptyline, tricyclic antidepressant; chromatographic standard. |
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Sigma-Aldrich
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