| Identification | Back Directory | [Name]
BEPRIDIL | [CAS]
64706-54-3 | [Synonyms]
Vascor
Bepadin
BEPRIDIL
ORG-5730
CERM-1978
BEPRIDIL USP/EP/BP
Bepridil free base
Bepridil hydrochloride monohydrate/bepridil
N-Benzyl-N-(3-isobutoxy-2-(pyrrolidin-1-yl)propyl)aniline
1-[2-(N-Benzylanilino)-1-(isobutoxymethyl)ethyl]pyrrolidine
N-[(2R)-3-(2-methylpropoxy)-2-(1-pyrrolidinyl)propyl]-N-(phenylmethyl)aniline
1-pyrrolidineethanamine,beta-((2-methylpropoxy)methyl)-n-phenyl-n-(phenylmethy
1-Pyrrolidineethanamine, β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)- | [Molecular Formula]
C24H34N2O | [MDL Number]
MFCD00868313 | [MOL File]
64706-54-3.mol | [Molecular Weight]
366.54 |
| Chemical Properties | Back Directory | [Boiling point ]
bp0.1 184°; bp0.5 192° | [density ]
1.0392 (rough estimate) | [refractive index ]
nD20 1.5538 | [storage temp. ]
2-8°C | [pka]
9.21±0.20(Predicted) | [Water Solubility ]
7.43g/L(37 ºC) |
| Hazard Information | Back Directory | [Chemical Properties]
Slightly yellow viscous liquid, boiling point 184°C/13.3Pa, 192°C/66.7Pa. ND20 1.5538. Bepridil Hydrochloride: C24H34N2O·HCI·H2O. [74764-40-2]. Needle-shaped crystals, melting point 91°C±2°C. Acute toxicity LD50 in mice (mg/kg): 1955 mg/kg oral, 23.5 mg/kg intravenous. | [Uses]
Bepridil is protective against Ebola virus. Bepridil is used in biological study of shortening of electromechnical window in ketamine/xylazine-anesthetized guinea pig model improved QTc interval prolongation and assessed pro-arrhythmic risk during early drug development. Bepridil is also used in therapeutic use in novel high/low solubility classification methods for new molecular entities. | [Definition]
ChEBI: A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl. | [Enzyme inhibitor]
This substituted pyrrolidine (FWfree-base = 366.55 g/mol) is a calcium channel
blocker that inhibits the Na+/Ca2+ exchange, exhibiting antiarrhythmic,
antianginal, and vasodilatory properties. Bepridil inhibits the growth of
certain brain tumors in vitro. Bepridil also binds to troponin C. Target (s) :
Ca2+ channels; ATP-sensitive K+ channels; Na+-activated K+
channels. |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Pharma Affiliates
|
| Tel: |
172-5066494 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList694812/0_EN.htm |
|