| Identification | Back Directory | [Name]
4-chloro-2-methylquinazoline | [CAS]
6484-24-8 | [Synonyms]
4-chloro-2-methylquinazoline
Quinazoline, 4-chloro-2-Methyl- | [Molecular Formula]
C9H7ClN2 | [MDL Number]
MFCD05666292 | [MOL File]
6484-24-8.mol | [Molecular Weight]
178.62 |
| Chemical Properties | Back Directory | [Melting point ]
86-88 °C | [Boiling point ]
211.2±23.0 °C(Predicted) | [density ]
1.292±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
solid | [pka]
1.28±0.30(Predicted) | [Appearance]
Off-white to yellow Solid | [InChI]
InChI=1S/C9H7ClN2/c1-6-11-8-5-3-2-4-7(8)9(10)12-6/h2-5H,1H3 | [InChIKey]
HAAZMOAXEMIBAJ-UHFFFAOYSA-N | [SMILES]
N1=C2C(C=CC=C2)=C(Cl)N=C1C |
| Hazard Information | Back Directory | [Uses]
4-Chloro-2-methylquinazoline is primarily used as a key intermediate in pharmaceutical research and chemical biology studies, particularly in the synthesis of novel drug molecules with biological activities such as anti-tumor and antibacterial effects. | [Synthesis]
The general procedure for the synthesis of 4-chloro-2-methylquinazoline from 4-hydroxy-2-methylquinazoline was as follows: first, starting from commercially purchased 2-methylquinazolin-4(3H)-one, the chlorination reaction was carried out at the 4-position using POCl3 according to the microwave-assisted procedure as previously reported [25], which ultimately afforded 4-chloro-2-methylquinazoline in 73% yield. Subsequently, the product was applied to the synthesis of the intermediate according to the general DMAP-catalyzed procedure described in κ 3.1.3 to give molecule 37 as a beige powder in 45% yield. The melting point of the product was 118 °C (isopropanol).1H NMR (200 MHz, CDCl3) δ = 8.33 (d, J = 8 Hz, 1H), 7.95-7.83 (m, 3H), 7.65-7.56 (m, 2H), 7.42-7.25 (m, 2H), 2.59 (s, 3H), 2.47 (s, 3H).13C NMR (50 MHz, CDCl3) δ=197.9,166.3,163.7,152.0,150.9,134.3,133.3,132.0,130.1,127.1,127.0,126.0,123.8,123.4,114.3,30.1,26.2. LC-MS (ESI+) tR 4.60 min, m/z [M+H]+ 279.19. molecular weight: 278.31 g/mol. calculated value of C17H14N2O2: C, 73.37; H, 5.07; N, 10.07. measured value: C, 73.82; H, 5.11; N, 9.93. | [References]
[1] Synthetic Communications, 2011, vol. 41, # 24, p. 3644 - 3653
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 6, p. 840 - 847
[3] MedChemComm, 2013, vol. 5, # 11, p. 1700 - 1707
[4] Tetrahedron, 2014, vol. 70, # 44, p. 8257 - 8266
[5] European Journal of Medicinal Chemistry, 2016, vol. 119, p. 34 - 44 |
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