| Identification | Back Directory | [Name]
10,13-dimethyl-17-oxo-3-sulfooxy-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene | [CAS]
651-48-9 | [Synonyms]
Formylisoglutamic acid
Abiraterone Impurity 73
Abiraterone Impurity 54
Dehydroepiandrosterone Sulfate
DEHYDROEPIANDROSTERONESULPHATE
(3β)-3-(Sulfooxy)androst-5-en-17-one
Androst-5-en-17-one, 3-(sulfooxy)-, (3β)-
DHEA Sulfate
DISCONTINUED. Please see S673250
Prasterone Sulfate Sports Nutrition Supplements Prasterone Sodium Sulfate 651-48-9
10,13-dimethyl-17-oxo-3-sulfooxy-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene
10,13-dimethyl-17-oxo-3-sulfooxy-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene USP/EP/BP
[(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate
sulfuric acid [(3S,8R,9S,10R,13S,14S)-17-keto-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] ester | [Molecular Formula]
C19H28O5S | [MDL Number]
MFCD00242651 | [MOL File]
651-48-9.mol | [Molecular Weight]
368.49 |
| Chemical Properties | Back Directory | [Melting point ]
190-192 °C | [Boiling point ]
468.81°C (rough estimate) | [density ]
1.1763 (rough estimate) | [refractive index ]
1.5300 (estimate) | [form ]
Solid | [pka]
-3.51±0.18(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses[1][2][3]. | [Definition]
ChEBI: A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone. | [in vivo]
DHEAS chronic administration produces a dose-dependent effect on performance[3].
| Animal Model: | Sixty-four male Sprague-Dawley rats, approximately 90 days of age (300-400 g)[3]. | | Dosage: | 5, 10, or 20 mg/kg. | | Administration: | Subcutaneous injection starting 7 days post-surgery and 1 h prior to all behavioral testing. | | Result: | Significantly effective in improving latency to reach the platform as compared to injured rats receiving vehicle. |
| [IC 50]
Human Endogenous Metabolite | [References]
[1] E E Baulieu, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91. DOI:10.1073/pnas.95.8.4089
[2] C R Parker Jr, et al. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids. 1999 Sep;64(9):640-7. DOI:10.1016/s0039-128x(99)00046-x
[3] Stuart W Hoffman, et al. The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003 Sep;20(9):859-70. DOI:10.1089/089771503322385791 |
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