| Identification | Back Directory | [Name]
1-(METHYLSULFONYL)PIPERIDIN-4-AMINE HYDROCHLORIDE | [CAS]
651057-01-1 | [Synonyms]
1-(Methylsulfonyl)-4-piperidinaMine HCl
1-(Methylsulfonyl)piperidin-4-amine, HCl
1-(METHYLSULFONYL)PIPERIDIN-4-AMINE HCl SALT
1-methylsulfonyl-4-piperidinamine hydrochloride
1-Methanesulfonylpiperidin-4-aMine hydrochloride
1-(METHYLSULFONYL)PIPERIDIN-4-AMINE HYDROCHLORIDE
4-Amino-1-(methylsulfonyl)piperidine Hydrochloride
1-METHANESULFONYL-PIPERIDIN-4-YLAMINE HYDROCHLORIDE
4-AMino-1-(Methanesulfonyl)piperidine hydrochloride | [Molecular Formula]
C6H15ClN2O2S | [MDL Number]
MFCD08690153 | [MOL File]
651057-01-1.mol | [Molecular Weight]
214.714 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C6H14N2O2S.ClH/c1-11(9,10)8-4-2-6(7)3-5-8;/h6H,2-5,7H2,1H3;1H | [InChIKey]
BASBDQBWDDKEDK-UHFFFAOYSA-N | [SMILES]
N1(S(C)(=O)=O)CCC(N)CC1.Cl |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 1-methylsulfonyl-4-aminopiperidine hydrochloride from 1-MS-4-Boc-aminopiperidine was as follows: 4-(N-Boc-amino)-1-methanesulfonylpiperidine (3.1 g, 11.15 mmol) was dissolved in 4 M HCl/dioxane solution (40 ml) and the reaction was stirred for 24 h at room temperature. After completion of the reaction, the reaction mixture was concentrated in vacuum. The resulting residue was azeotropically dried by mixing with toluene:methanol (1:1, v/v) to give the final 1-methylsulfonyl-piperidin-4-ylamine hydrochloride as a white solid (2.4 g, 100% yield). | [References]
[1] Patent: WO2006/77414, 2006, A1. Location in patent: Page/Page column 164
[2] Patent: EP2261213, 2010, A1. Location in patent: Page/Page column 44-45 |
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