| Identification | Back Directory | [Name]
MK-0752 sodiuM salt | [CAS]
656810-87-6 | [Synonyms]
MK-0752 Sodium
MK-0752 sodiuM salt
HYCFVHYFYXEBHI-NHINQKSTSA-N
MK0752 Sodium,MK 0752 Sodium | [Molecular Formula]
C21H22ClF2NaO4S | [MDL Number]
MFCD25976557 | [MOL File]
656810-87-6.mol | [Molecular Weight]
466.9 |
| Hazard Information | Back Directory | [Uses]
MK-0752 sodium is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 sodium crosses the blood-brain barrier. MK-0752 sodium reduces newly generated CNS Aβ in vivo[1][2]. | [References]
[1] Cook JJ, et al. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci. 2010;30(19):6743-6750. DOI:10.1523/JNEUROSCI.1381-10.2010
[2] Krop I, et al. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J Clin Oncol. 2012;30(19):2307-2313. DOI:10.1200/JCO.2011.39.1540 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|