| Identification | Back Directory | [Name]
1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE | [CAS]
658-89-9 | [Synonyms]
4-Trifluoromethoxy-1,2-diaminobenzene
1,2-DIAMINO-4-(TRIFLUOROMETHOXY)BENZENE
4-(TRIFLUOROMETHOXY)BENZENE-1,2-DIAMINE
4-(TRIFLUOROMETHOXY)-1,2-PHENYLENEDIAMINE
4-(Trifluoromethoxy)benzene-1,2-diamine 97%
1,2-Diamino-4-(trifluoromethoxy)benzene, 4-(Trifluoromethoxy)phenylene-1,2-diamine | [Molecular Formula]
C7H7F3N2O | [MDL Number]
MFCD03094278 | [MOL File]
658-89-9.mol | [Molecular Weight]
192.14 |
| Chemical Properties | Back Directory | [Boiling point ]
106-108 °C(Press: 5 Torr) | [density ]
1.429±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
3.30±0.10(Predicted) | [color ]
Dark Brown to Black | [Stability:]
Air Sensitive |
| Hazard Information | Back Directory | [Uses]
1,?2-?Diamino-?4-?(trifluoromethoxy)?benzene is a useful synthetic compound. | [Synthesis]
General procedure for the synthesis of 4-(trifluoromethoxy)benzene-1,2-diamine from 2-nitro-4-trifluoromethoxyaniline: a solution of 2-nitro-4-trifluoromethoxyaniline (25.0 g, 0.112 mol) in ethanol (200 mL) was slowly added to a solution of concentrated hydrochloric acid (330 mL) of tin chloride dihydrate (82.0 g, 0.363 mol). The reaction mixture was stirred at 70-80°C for 0.5 hours. Upon completion of the reaction, the mixture was cooled to 0-5°C and the pH was adjusted to 11-12 with 40% sodium hydroxide solution.Subsequently, the reaction product was extracted with ether (2 x 200 mL). The organic phases were combined, washed with water and dried over anhydrous sodium sulfate. Finally, the solvent was removed by evaporation under reduced pressure to give 4-(trifluoromethoxy)benzene-1,2-diamine as a brown oil (21.1 g, 98% yield). | [References]
[1] Patent: WO2006/50148, 2006, A2. Location in patent: Page/Page column 38
[2] Patent: WO2008/75109, 2008, A1. Location in patent: Page/Page column 160
[3] Patent: WO2006/130673, 2006, A1. Location in patent: Page/Page column 115
[4] Patent: WO2006/22954, 2006, A2. Location in patent: Page/Page column 24
[5] Patent: US2014/315963, 2014, A1. Location in patent: Paragraph 0228 |
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