| Identification | Back Directory | [Name]
7-hydroxyquinoline-3-carboxylic acid | [CAS]
659730-27-5 | [Synonyms]
7-hydroxyquinoline-3-carboxylic acid
7-oxo-1H-quinoline-3-carboxylic acid
3-Quinolinecarboxylic acid, 7-hydroxy- | [Molecular Formula]
C10H7NO3 | [MDL Number]
MFCD18417142 | [MOL File]
659730-27-5.mol | [Molecular Weight]
189.17 |
| Chemical Properties | Back Directory | [Melting point ]
>260 °C | [Boiling point ]
426.7±30.0 °C(Predicted) | [density ]
1.480±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
2.34±0.30(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Step E. Synthesis of 7-hydroxyquinoline-3-carboxylic acid. Ethyl 7-methoxyquinoline-3-carboxylate (7.03 g, 30.4 mmol) was dissolved in 48% aqueous hydrobromic acid (150 mL) and heated to reflux at 105 °C for 88.5 hours. After completion of the reaction, it was cooled to room temperature and the precipitate precipitated was collected by filtration to afford the title compound 7-hydroxyquinoline-3-carboxylic acid as a brown solid (5.2 g, 90% yield). 1H NMR (400 MHz, DMSO-d6) δ 12.05-11.67 (m, 1H), 9.49 (d, J = 2.0 Hz, 1H), 9.43 (s, 1H), 8.39 (d, J = 9.8 Hz, 1H), 7.55-7.51 (m, 2H). Mass spectrum (ESI) [M + H]+ m/z = 190.2. | [References]
[1] Patent: US2014/275548, 2014, A1. Location in patent: Paragraph 0363 |
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