| Identification | Back Directory | [Name]
Carbamic acid, N-[2-[6-[[2-(acetylamino)-4-benzothiazolyl]oxy]-4-pyrimidinyl]-5-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester | [CAS]
659731-59-6 | [Synonyms]
AMG8163
AMG-8163
AMG 8163
Carbamic acid, N-[2-[6-[[2-(acetylamino)-4-benzothiazolyl]oxy]-4-pyrimidinyl]-5-(trifluoromethyl)phenyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C25H22F3N5O4S | [MOL File]
659731-59-6.mol | [Molecular Weight]
545.53 |
| Hazard Information | Back Directory | [Description]
AMG8163 is a vanilloid receptor TRPV1 antagonist. | [Uses]
AMG8163 is an orally active antagonist for TRPV1. AMG8163 inhibits Capsaicin (HY-10448)-induced flinch in rats models, and exhibits anti-hyperalgesia effects in multiple pain models[1]. | [References]
[1] Gavva NR, et al., Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther. 2007 Oct;323(1):128-37. DOI:10.1124/jpet.107.125674 |
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