| Identification | Back Directory | [Name]
L-Arginine, glycyl-L-seryl-O-(1-oxooctyl)-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-, trifluoroacetate (salt) | [CAS]
659739-25-0 | [Synonyms]
glycyl-L-seryl-O-(1-oxooctyl)-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-L-arginine,2,2,2-trifluoroacetate
L-Arginine, glycyl-L-seryl-O-(1-oxooctyl)-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-lysyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-, trifluoroacetate (salt) | [Molecular Formula]
C149H246F3N45O44 | [MOL File]
659739-25-0.mol | [Molecular Weight]
3428.87 |
| Hazard Information | Back Directory | [Description]
Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).1,2 It increases intracellular calcium in CHO cells expressing rat GHS-R (EC50 = 2.5 nM) and induces GH release from primary rat pituitary cells (EC50 = 2.1 nM).1 Ghrelin (10 nM) also reduces glucose-, arginine-, and carbachol-induced insulin release and arginine-induced somatostatin release from perfused rat pancreas.3 It increases GH plasma levels in anesthetized rats, but does not affect follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, thyroid-stimulating hormone (TSH), or adrenocorticotropic hormone (ACTH) levels when administered at a dose of 10 μg per animal.1 Ghrelin increases gastric motility in rats in a dose-dependent manner when administered intracranially into the lateral septum and increases food intake and body weight when administered intracerebroventricularly at a dose of 1 μg per animal.4,5WARNING This product is not for human or veterinary use. | [References]
[1] MASAYASU KOJIMA. Ghrelin is a growth-hormone-releasing acylated peptide from stomach[J]. Nature, 1999, 402 6762: 656-660. DOI: 10.1038/45230
[2] SUZANNE L. DICKSON . The role of the central ghrelin system in reward from food and chemical drugs[J]. Molecular and Cellular Endocrinology, 2011, 340 1: Pages 80-87. DOI: 10.1016/j.mce.2011.02.017
[3] E. M. EGIDO. Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion.[J]. European Journal of Endocrinology, 2002, 146 2 1: 241-244. DOI: 10.1530/eje.0.1460241
[4] YANLING GONG. Effects of ghrelin on gastric distension sensitive neurons and gastric motility in the lateral septum and arcuate nucleus regulation.[J]. Journal of Gastroenterology, 2014, 49 2: 219-230. DOI: 10.1007/s00535-013-0789-y
[5] J. KAMEGAI. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats.[J]. Diabetes, 2001, 50 11 1: 2438-2443. DOI: 10.2337/diabetes.50.11.2438 |
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