| Identification | Back Directory | [Name]
5,7,8,4''-TETRAMETHOXYFLAVONE | [CAS]
6601-66-7 | [Synonyms]
8-Tetramethoxyflavone
5,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one
5,7,8,4'-
tetramethoxyflavone
6-Demethoxytangeretin
4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-(4-methoxyphenyl)- | [Molecular Formula]
C19H18O6 | [MDL Number]
MFCD03427696 | [MOL File]
6601-66-7.mol | [Molecular Weight]
342.34 |
| Chemical Properties | Back Directory | [Melting point ]
216-217℃ (methanol ) | [Boiling point ]
536.9±50.0 °C(Predicted) | [density ]
1.243±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
Pale yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Citrus aurantium. | [Uses]
6-Demethoxytangeretin is a flavonoid compound that can be isolated from Citrus reticulata. 6-Demethoxytangeretin has anti-inflammatory and anti-allergic activities and can inhibit the production of IL-6 and the expression of related genes in human mast cells through the ALK and MAPK pathways. 6-Demethoxytangeretin can promote CRE-mediated transcription in hippocampal neurons[1][2]. | [References]
[1] Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5. DOI:10.1248/bpb.b13-00875
[2] Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409. DOI:10.1007/s00702-013-1025-x |
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