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Tunicamine is a reversible inhibitor of polyprenol-phosphate. | [Uses]
Tunicamine is a high carbohydrate antibiotic that is part of the structure of Tunicamycin. Tunicamycin is a nucleoside antibiotic and a reversible polyprenol-phosphate inhibitor[1][2][3]. | [References]
[1] Astani EK,et al. Intermolecular Interactions of Nucleoside Antibiotic Tunicamycin with On-Target MraYCB-TUN and Off-Target DPAGT1-TUN in the Active Sites Delineated by Quantum Mechanics/Molecular Mechanics Calculations. ACS Omega. 2022 Sep 6;7(37):32970-32987. DOI:10.1021/acsomega.2c02213
[2] Sasai H, et al. Synthetic Approach Toward Antibiotic Tunicamycins-VII Synthesis of Tunicamine and Tunicaminyl Uracil Derivative. Journal of Carbohydrate Chemistry, 1985, 4(1): 99-112.
[3] Tsvetanova BC, et al. Biosynthesis of tunicamycin and metabolic origin of the 11-carbon dialdose sugar, tunicamine. J Biol Chem. 2002 Sep 20;277(38):35289-96. DOI:10.1074/jbc.M201345200 |
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