| Identification | Back Directory | [Name]
(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine | [CAS]
662164-09-2 | [Synonyms]
D3-βArr
D3-ΒARR
C 00379308
D3- beta Arr
NCGC00379308
D3-βArr?- NCg
D3-βArr- NCGC 00379308
D3-betaArr >=98% (HPLC)
D3-βArr?- NCGC 00379308
4-Quinazolinamine, N-(1-phenylethyl)-2-(1-piperazinyl)-
(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine | [Molecular Formula]
C20H23N5 | [MDL Number]
MFCD04077665 | [MOL File]
662164-09-2.mol | [Molecular Weight]
333.43 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 125 mg/mL (374.89 mM) | [form ]
Solid | [color ]
White to off-white | [InChI]
1S/C20H23N5/c1-15(16-7-3-2-4-8-16)22-19-17-9-5-6-10-18(17)23-20(24-19)25-13-11-21-12-14-25/h2-10,15,21H,11-14H2,1H3,(H,22,23,24) | [InChIKey]
LOGWGZNWEWFTJV-UHFFFAOYSA-N | [SMILES]
CC(C1=CC=CC=C1)NC2=NC(N3CCNCC3)=NC4=CC=CC=C42 |
| Hazard Information | Back Directory | [Uses]
D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro[1]. | [Biological Activity]
D3-βArr is a positive allosteric modulator of TSHR (thyrotropin receptor) for β-Arr 1-mediated signaling th at initiates translocation of β-Arr 1 by direct TSHR activationwhile showing no agonistic effect on cAMP production. D3-βarr is a positive allosteric modulator for TSH-enhanced osteoblast differentiation. | [References]
[1] Neumann S, et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45. DOI:10.1124/jpet.117.244095 |
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| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|