| Identification | Back Directory | [Name]
7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL | [CAS]
6632-09-3 | [Synonyms]
AURORA 23227
AKOS BBS-00001111
NSC57969 >=98% (HPLC)
OTAVA-BB BB7010150234
7-(PIPERIDIN-1-YLMETHYL)QUINOLIN-8-OL
8-Quinolinol, 7-(1-piperidinylmethyl)-
7-(1-piperidinylmethyl)-8-hydroxyquinoline | [Molecular Formula]
C15H18N2O | [MDL Number]
MFCD00469245 | [MOL File]
6632-09-3.mol | [Molecular Weight]
242.32 |
| Chemical Properties | Back Directory | [Melting point ]
194 °C | [Boiling point ]
402.4±30.0 °C(Predicted) | [density ]
1.202±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 5mg/mL, clear (warmed) | [form ]
powder | [pka]
3.81±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
NSC-57969 is a multidrug resistant (MDR)-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines[1]. | [Biological Activity]
NSC57969 is a MDR-selective compound th at exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinomaand MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp. | [References]
[1] András Füredi, et al. Identification and Validation of Compounds Selectively Killing Resistant Cancer: Delineating Cell Line-Specific Effects from P-Glycoprotein-Induced Toxicity. Mol Cancer Ther. 2017 Jan;16(1):45-56. DOI:10.1158/1535-7163.MCT-16-0333-T |
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Energy Chemical
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Merck KGaA
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OTAVA chemicals
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www.otavachemicals.com |
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