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663599-10-8

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663599-10-8 Structure

663599-10-8 Structure
IdentificationBack Directory
[Name]

2,5-Dioxopyrrolidin-1-yl 4-((3-(dimethylcarbamoyl)pyridin-4-yl)disulfanyl)pentanoate
[CAS]

663599-10-8
[Synonyms]

DMAC-SPP
2,5-Dioxopyrrolidin-1-yl 4-((3-(dimethylcarbamoyl)pyridin-4-yl)disulfanyl)pentanoate
[Molecular Formula]

C17H21N3O5S2
[MDL Number]

MFCD20227697
[MOL File]

663599-10-8.mol
[Molecular Weight]

411.5
Chemical PropertiesBack Directory
[Boiling point ]

579.6±60.0 °C(Predicted)
[density ]

1.39±0.1 g/cm3(Predicted)
[pka]

2.60±0.36(Predicted)
Hazard InformationBack Directory
[Uses]

DMAC-SPP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50]

Disulfide Cleavable Linker; Cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
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