| Identification | Back Directory | [Name]
1-methyl-1H-imidazol-2-amine | [CAS]
6646-51-1 | [Synonyms]
CAS:6646-51-1
1-methylimidazol-2-amine
1-Methyl-2-aminoimidazole
2-Amino-1-methylimidazole
1-methyl-1H-imidazol-2-amine
1H-IMidazol-2-aMine,1-Methyl-
1-Methyl-1H-imidazol-2-ylamine
2-AMino-1-Methyl-1H-iMidazole, 97%
1-methyl-1H-imidazol-2-amine(SALTDATA: HCl) | [Molecular Formula]
C4H7N3 | [MDL Number]
MFCD01646103 | [MOL File]
6646-51-1.mol | [Molecular Weight]
97.1203 |
| Chemical Properties | Back Directory | [Boiling point ]
255℃ | [density ]
1.22 | [Fp ]
108℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [form ]
solid | [pka]
8.53±0.25(Predicted) | [color ]
White | [InChI]
InChI=1S/C4H7N3/c1-7-3-2-6-4(7)5/h2-3H,1H3,(H2,5,6) | [InChIKey]
NQCJWEXYVVFKBT-UHFFFAOYSA-N | [SMILES]
C1(N)N(C)C=CN=1 |
| Hazard Information | Back Directory | [Uses]
1-Methyl-1H-imidazol-2-amine, is an intermediate in the synthesis of variety of antibacterial and antitumor agents. | [Synthesis]
General procedure for the synthesis of 2-amino-1-methylimidazole from 1-methyl-2-nitro-1H-imidazole: To a stirred solution of 1-methyl-2-nitro-1H-imidazole (500 mg, 3.9 mmol) in acetic acid (15 mL) was added iron powder (1.34 g, 24 mmol). The reaction mixture was stirred at 80 °C overnight. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated under vacuum. The residue was purified by preparative high performance liquid chromatography (HPLC) using a C18 column with an elution gradient of 10% to 90% acetonitrile/water (containing 0.1% formic acid) solution to afford 2-amino-1-methylimidazole (66 mg, 17% yield) as a yellow solid. | [References]
[1] Patent: WO2016/4272, 2016, A1. Location in patent: Paragraph 00799 |
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