| Identification | Back Directory | [Name]
H-D-GLU(TRP-OH)-OH | [CAS]
66471-20-3 | [Synonyms]
Bestim
Scv 07
Scv-07
GLU-TRP
GAMMA-GLU-TRP
H-g-Glu-Trp-OH
H-GLU(TRP-OH)-OH
H-D-gGlu-L-Trp-OH
H-D-GLU(TRP-OH)-OH
H-GAMMA-GLU-TRP-OH
H-GAMMA-D-GLU-TRP-OH
L-gamma-Glutamyl-L-tryptophan
L-Tryptophan, L-gamma-glutamyl-
L-Tryptophan, N-L-gamma-glutamyl-
2-amino-5-[[1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid | [Molecular Formula]
C16H19N3O5 | [MDL Number]
MFCD00057875 | [MOL File]
66471-20-3.mol | [Molecular Weight]
333.34 |
| Hazard Information | Back Directory | [Uses]
Bestim is a dipeptide, which exhibits high affinity to murine peritoneal macrophages, thymocytes, and plasma membranes isolated from these cells, with Kds of 3.1, 2.1, 18.6 and 16.7 nM, respectively. Bestim inhibits adenylate cyclase in the membranes of murine macrophages and thymocytes. Bestim exhibits immunomodulatory efficacy[1]. | [Definition]
ChEBI: A glutamyl-L-amino acid obtained by formal condensation of the gamma-carboxy group of glutamic acid with the amino group of tryptophan. | [References]
[1] Kolobov AA, et al., Interaction of the synthetic immunomodulatory dipeptide bestim with murine macrophages and thymocytes. Bioorg Khim. 2008 Jan-Feb;34(1):43-9. Russian. DOI:10.1134/s1068162008010044 |
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