| Identification | Back Directory | [Name]
BOC-4-ABZ-OH | [CAS]
66493-39-8 | [Synonyms]
BOC-PABA
AKOS 90574
Boc-PABA-OH
BOC-P-ABZ-OH
BOC-4-ABZ-OH
RARECHEM EM WB 0012
N-Boc-4-aminobenzoic
BOC-4-ABZ-OH USP/EP/BP
BOC-4-AMINOBENZOIC ACID
BOC-P-AMINOBENZOIC ACID
Boc-4-Abz-OH >=98.0% (T)
4-(BOC-AMINO)BENZOIC ACID
N-BOC-4-AMINOBENZOIC ACID
Boc-4-aminobenzoic acid98+%
N-Boc-4-aminobenzoicacid,97%
(Tert-Butoxy)Carbonyl 4-Abz-OH
Boc-4-Abz-OH(Boc-4-aMinobenzoic Acid)
4-TERT-BUTOXYCARBONYLAMINO-BENZOIC ACID
4-(T-BUTYLOXYCARBONYLAMINO)-BENZOIC ACID
n-tert-butoxycarbonyl-4-aminobenzoic acid
4-(N-tert-Butoxycarbonyl)aMinobenzoic Acid
4-(TERT-BUTYLOXYCARBONYLAMINO)-BENZOIC ACID
N-ALPHA-T-BUTOXYCARBONYL-P-AMINOBENZOIC ACID
N-tert-butoxycarbonyl-para-aminobenzoic acid
4-(tert-Butoxycarbonylamino)benzoic Acid >
N-ALPHA-T-BUTOXYCARBONYL-4-AMINO-BENZOIC ACID
4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoicaci
4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoic acid
Benzoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-
4-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-1-cyclohexanecarboxylate | [EINECS(EC#)]
676-774-4 | [Molecular Formula]
C12H15NO4 | [MDL Number]
MFCD00037428 | [MOL File]
66493-39-8.mol | [Molecular Weight]
237.25 |
| Chemical Properties | Back Directory | [Melting point ]
~200 °C (dec.)
| [Boiling point ]
336.2±25.0 °C(Predicted) | [density ]
1.242±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
soluble in Methanol | [form ]
Powder | [pka]
4.33±0.10(Predicted) | [color ]
Beige | [BRN ]
2115614 | [Major Application]
peptide synthesis | [InChI]
1S/C12H15NO4/c1-12(2,3)17-11(16)13-9-6-4-8(5-7-9)10(14)15/h4-7H,1-3H3,(H,13,16)(H,14,15) | [InChIKey]
ZJDBQMWMDZEONW-UHFFFAOYSA-N | [SMILES]
CC(C)(C)OC(=O)Nc1ccc(cc1)C(O)=O |
| Hazard Information | Back Directory | [Chemical Properties]
Light brown powder | [Uses]
4-(N-tert-Butoxycarbonyl)aminobenzoic Acid is the tert-Butyloxycarbonyl group protected derivative of 4-Aminobenzoic Acid (A591500), an widely distributed B complex factor in nature. | [reaction suitability]
reaction type: Boc solid-phase peptide synthesis | [Synthesis]
General procedure for the synthesis of 4-(N-tert-butoxycarbonylamino)benzoic acid from di-tert-butyl dicarbonate and p-aminobenzoic acid: sodium hydroxide (1.46 g, 36.5 mmol) was added to a mixture of dioxane (70 mL) and water (35 mL) of 4-aminobenzoic acid (5.00 g, 36.5 mmol), followed by di-tert-butyl dicarbonate (11.9 g, 54.8 mmol). The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation and aqueous 3N hydrochloric acid was added slowly and dropwise to the residue to adjust the pH to 3. The precipitate precipitated was collected by filtration, washed with water and dried to afford the target product 4-(N-tert-butoxycarbonylamino)benzoic acid (8.28 g, 96% yield) as a white solid. | [References]
[1] Journal of Medicinal Chemistry, 2001, vol. 44, # 3, p. 441 - 452
[2] Journal of Catalysis, 2016, vol. 340, p. 344 - 353
[3] Tetrahedron Letters, 2003, vol. 44, # 37, p. 7103 - 7106
[4] Synthesis, 2005, # 7, p. 1061 - 1068
[5] Chemistry - A European Journal, 2003, vol. 9, # 2, p. 557 - 560 |
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