| Identification | Back Directory | [Name]
Fosmidomycin | [CAS]
66508-53-0 | [Synonyms]
Antibiotic FR-31705
10 Mg, 50 Mg, 100 Mg, 1g
Fosmidomycin sodium salt hydrate
3-(Formylhydroxyamino)propylphosphonic acid
3-Phosphono 1-(N-formylhydroxyamino)propane
(3-(N-hydroxyforMaMido)propyl)phosphonic acid
Phosphonic acid, P-[3-(formylhydroxyamino)propyl]-
(3-(N-Hydroxyformamido)propyl)phosphonic acid sodium salt | [Molecular Formula]
C4H10NO5P | [MDL Number]
MFCD00865023 | [MOL File]
66508-53-0.mol | [Molecular Weight]
183.1 |
| Chemical Properties | Back Directory | [Melting point ]
158-160° (dec); mp 160-166° (dec) (Hemmi) | [storage temp. ]
-20°C | [solubility ]
H2O: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 20mg/mL, clear | [InChI]
1S/C4H10NO5P/c6-4-5(7)2-1-3-11(8,9)10/h4,7H,1-3H2,(H2,8,9,10) | [InChIKey]
GJXWDTUCERCKIX-UHFFFAOYSA-N | [SMILES]
[P](=O)(O)(O)CCCN(O)C=O |
| Safety Data | Back Directory | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Toxicity]
LD50 in mice and rats (mg/kg): >11000 orally; ~8000 s.c. (Wiesner, 2003) |
| Hazard Information | Back Directory | [Uses]
Fosmidomycin sodium salt hydrate has been used as an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a study to determine monotropin carvacrol biosynthesis in Satureja khuzistanica plant. | [Definition]
ChEBI: Propylphosphonic acid in which one of the hydrogens at position 3 is substituted by a formyl(hydroxy)amino group. An antibiotic obtained from Streptomyces lavendulae, it specifically inhibits DXP reductoisomerase (EC 1.1.1.267), a key enzyme i
the non-mevalonate pathway of isoprenoid biosynthesis. | [Biochem/physiol Actions]
Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) (MEP synthase): an antimalarial compound. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway). |
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BOC Sciences
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1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
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