| Identification | Back Directory | [Name]
[2S-[2R*[R*(R*)]]]-N-[2-[4-(aminocarbonyl)-3-thiazolidinyl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl]-6-oxopiperidine-2-carboxamide | [CAS]
66537-55-1 | [Synonyms]
Brn 5174437
Einecs 266-396-4
(2S)-N-[(1S)-2-[(4S)-4-(Aminocarbonyl)thiazolidin-3-yl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl]-6-oxo-2-piperidinecarboxamide
(2S-(2R*(R*(R*))))-N-(2-(4-(Aminocarbonyl)-3-thiazolidinyl)-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl)-6-oxopiperidine-2-carboxamide
[2S-[2R*[R*(R*)]]]-N-[2-[4-(aminocarbonyl)-3-thiazolidinyl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl]-6-oxopiperidine-2-carboxamide
2-Piperidinecarboxamide, N-(2-(4-(aminocarbonyl)-3-thiazolidinyl)-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl)-6-oxo-, (2S-(2R*(R*(R*))))-
2-Piperidinecarboxamide, N-[(1S)-2-[(4S)-4-(aminocarbonyl)-3-thiazolidinyl]-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl]-6-oxo-, (2S)- (9CI) | [EINECS(EC#)]
266-396-4 | [Molecular Formula]
C16H22N6O4S | [MDL Number]
MFCD01701265 | [MOL File]
66537-55-1.mol | [Molecular Weight]
394.45 |
| Hazard Information | Back Directory | [Uses]
MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome[1][2]. | [in vivo]
MK771 (5 mg/kg; i.p.) induces blinking and forepaw licking in mice[1].
MK771 (10 ng-10 μg/mouse; i.c.v.) produces a hyperthermic response in mice[2]. | Animal Model: | 20-30 g, male MF1 mice[1] | | Dosage: | 5 mg/kg | | Administration: | I.p. | | Result: | Induced blinking and forepaw licking in both acutely isolated and paired mice. |
| Animal Model: | 20-30 g, male MF1 mice[1] | | Dosage: | 0.25-60 mg/kg | | Administration: | I.p. | | Result: | Induced blinking was bell-shaped with an ED50 value of 1.72 mg/kg. |
| Animal Model: | 25-30 g, Male Swiss-Webster mice[2] | | Dosage: | 10 ng-10 μg/mouse | | Administration: | I.c.v. | | Result: | Produced a hyperthermic response for 4 h followed by a return to normal temperature. |
| [References]
[1] McCreary AC, et al. The thyrotrophin-releasing hormone analogue MK771 induces tic-like behaviours: the effects of dopamine D1 and D2 receptor antagonists. Eur J Pharmacol. 1999 Mar 12;369(1):1-9. DOI:10.1016/s0014-2999(99)00039-4
[2] Bhargava HN, et al. Comparative effects of thyrotropin releasing hormone, MK-771 and DN-1417 on morphine abstinence syndrome. Psychopharmacology (Berl). 1985;87(2):141-6. DOI:10.1007/BF00431797 |
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