| Identification | Back Directory | [Name]
5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | [CAS]
66611-26-5 | [Synonyms]
CS-1199
RU24969;RU 24969
5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
3-(1,2,3,6-Tetrahydropyridine-4-yl)-5-methoxy-1H-indole
1H-Indole, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-
5,6-dimethyl-2-(pyridin-4-yl)-2,3-dihydro-1H-benzo[d]imidazole
5-Methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole succinate
5-HT1B,Serotonin Receptor,fluid,RU 24969,5-HT1A,RU24969,locomotion,Inhibitor,5-HT Receptor,5-hydroxytryptamine Receptor,inhibit,RU-24969 | [Molecular Formula]
C14H16N2O | [MOL File]
66611-26-5.mol | [Molecular Weight]
228.29 |
| Chemical Properties | Back Directory | [Melting point ]
179-181 °C | [Boiling point ]
434.6±45.0 °C(Predicted) | [density ]
1.174±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 30 mg/mL (131.41 mM) | [form ]
Powder | [pka]
16.77±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
RU 24969 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion[1]. | [Definition]
ChEBI: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole is a member of indoles. | [in vivo]
RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1].
RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1]. | Animal Model: | Male Sprague-Dawley rats[1] | | Dosage: | 0.03, 0.3, 1.0, 3.0 mg/kg | | Administration: | A single s.c. | | Result: | Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg. |
| [IC 50]
5-HT1B Receptor: 0.38 nM (Ki); 5-HT1A Receptor: 2.5 nM (Ki) | [storage]
Store at -20°C | [References]
[1] Aronsen D, et, al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep; 124: 1-4. DOI:10.1016/j.pbb.2014.05.008
[2] Brazell MP, et, al. The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol. 1985 Sep; 86(1): 209-16. DOI:10.1111/j.1476-5381.1985.tb09451.x |
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SPIRO PHARMA
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Musechem
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www.musechem.com |
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Cckinase, Inc.
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