| Identification | Back Directory | [Name]
Guttiferone G | [CAS]
666174-75-0 | [Synonyms]
Guttiferone G
Bicyclo[3.3.1]non-3-ene-2,9-dione, 3-(3,4-dihydroxybenzoyl)-7-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-4-hydroxy-8-methyl-1,5-bis(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-, (1S,5S,7R,8S)- | [Molecular Formula]
C43H58O6 | [MOL File]
666174-75-0.mol | [Molecular Weight]
670.92 |
| Chemical Properties | Back Directory | [Boiling point ]
756.4±60.0 °C(Predicted) | [density ]
1.088±0.06 g/cm3(Predicted) | [pka]
4.50±1.00(Predicted) | [InChIKey]
XIKKSUTXFFVDEF-SSVAQFLFSA-N | [SMILES]
[C@@]12(C/C=C(/C)\C)C(=O)[C@@](C/C=C(/C)\C)(C[C@@H](C/C=C(\C)/CC/C=C(/C)\C)[C@]1(C)CC/C=C(\C)/C)C(O)=C(C(=O)C1=CC=C(O)C(O)=C1)C2=O |
| Hazard Information | Back Directory | [Uses]
Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla[1][2]. | [References]
[1] Williams RB, et al. A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest. Planta Med. 2003 Sep;69(9):864-6. DOI:10.1055/s-2003-43204
[2] Gey C, et al. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. Angew Chem Int Ed Engl. 2007;46(27):5219-22. DOI:10.1002/anie.200605207 |
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