| Identification | Back Directory | [Name]
Benzenesulfonamide, N-(3-chloro-4-fluorophenyl)-4-fluoro-3,5-dimethyl- | [CAS]
666699-46-3 | [Synonyms]
Benzenesulfonamide, N-(3-chloro-4-fluorophenyl)-4-fluoro-3,5-dimethyl- | [Molecular Formula]
C14H12ClF2NO2S | [MOL File]
666699-46-3.mol | [Molecular Weight]
331.77 |
| Chemical Properties | Back Directory | [Boiling point ]
437.7±55.0 °C(predicted) | [density ]
1.433±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [solubility ]
DMSO: 2 mg/mL, clear | [form ]
Solid | [pka]
7.01±0.10(predicted) | [color ]
White to light yellow | [InChI]
InChI=1S/C14H12ClF2NO2S/c1-8-5-11(6-9(2)14(8)17)21(19,20)18-10-3-4-13(16)12(15)7-10/h3-7,18H,1-2H3 | [InChIKey]
JVUSVLUQMXGABO-UHFFFAOYSA-N | [SMILES]
S(C1C=C(C(=C(C=1)C)F)C)(=O)(=O)NC1C=CC(=C(C=1)Cl)F |
| Hazard Information | Back Directory | [Uses]
TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT). TERT activator-1 promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. TERT activator-1 promotes adult neurogenesis and enhances neuromuscular function. TERT activator-1 reduces cellular senescence and systemic inflammation in aged mice, and can be used in the study of aging[1]. | [in vivo]
TERT activator-1 (6 mg/kg; intraperitoneal injection; 1-6 weeks) alleviates aging and promotes adult neurogenesis in naturally aging mice[1]. | Animal Model: | C57BL/6 mice aged 10-12 weeks old[1] | | Dosage: | 6 mg/kg | | Administration: | Intraperitoneal injection (i.p.); 1 week | | Result: | Significantly increased the level of TERT protein.
Reduced aging genetic traits including cell-cycle arrest and PML body.
Suppressed p16Ink4a and other senescence-associated secretory phenotype (SASP) components.
Induced signatures of organism growth and natural killer cell activation.
Increased in the levels of mBDNF in adult hippocampus. |
| Animal Model: | Naturally aged C57BL/6 mice aged 20-21 months old[1] | | Dosage: | 6 mg/kg | | Administration: | Intraperitoneal injection (i.p.); 3 times a week; 6 months | | Result: | Improves hippocampal-dependent cognitive function.
Enhances neuromuscular function.
Did not result in any overt adverse consequences.
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| [IC 50]
MEK1; MEK2; ERK1; ERK2 | [References]
[1] Shim HS, et al. TERT activation targets DNA methylation and multiple aging hallmarks. Cell. 2024 Jul 25;187(15):4030-4042.e13. |
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