| Identification | Back Directory | [Name]
SU 9516 | [CAS]
666837-93-0 | [Synonyms]
SU 9516
3-((1H-Imidazol-5-yl)methylene)-5-methoxyindolin-2-one
(Z)-3-((1H-iMidazol-5-yl)Methylene)-5-Methoxyindolin-2-one
1,3-Dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-2H-indol-2-one
2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-5-methoxy-
SU 9516;SU9516;(Z)-3-((1H-IMIDAZOL-5-YL)METHYLENE)-5-METHOXYINDOLIN-2-ONE
3-[1-(3H-IMIDAZOL-4-YL)-METH-(Z)-YLIDENE]-5-METHOXY-1,3-DIHYDRO-INDOL-2-ONE | [Molecular Formula]
C13H11N3O2 | [MDL Number]
MFCD17010284 | [MOL File]
666837-93-0.mol | [Molecular Weight]
241.25 |
| Chemical Properties | Back Directory | [Boiling point ]
601.5±55.0 °C(Predicted) | [density ]
1.383±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ~17 mg/mL | [form ]
crystalline | [pka]
11?+-.0.20(Predicted) | [color ]
brown | [InChI]
1S/C13H11N3O2/c1-18-9-2-3-12-10(5-9)11(13(17)16-12)4-8-6-14-7-15-8/h2-7H,1H3,(H,14,15)(H,16,17) | [InChIKey]
QNUKRWAIZMBVCU-UHFFFAOYSA-N | [SMILES]
[nH]1cncc1C=C2c3c(ccc(c3)OC)NC2=O |
| Hazard Information | Back Directory | [Uses]
SU 9516 is a 3-substituted indolinone CDK inhibitor with potent and selective inhibition towards cyclin-dependant kinases. | [Uses]
SU9516 is a selectively potent ATP-competitive inhibitor of CDKs. | [Definition]
ChEBI: 3-(1H-imidazol-5-ylmethylidene)-5-methoxy-1H-indol-2-one is a member of indoles. | [Biological Activity]
Cell permeable: yes''Primary Target
Cdk2/A''Product competes with ATP.''Reversible: yes''Target IC50: 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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