| Identification | Back Directory | [Name]
3-(6,7-dimethoxy-3,3-dimethyl-4H-isoquinolin-1-yl)chromen-2-one | [CAS]
667427-75-0 | [Synonyms]
TRPC6-PAM-C20
3-(6,7-dimethoxy-3,3-dimethyl-4H-isoquinolin-1-yl)chromen-2-one
2H-1-Benzopyran-2-one, 3-(3,4-dihydro-6,7-dimethoxy-3,3-dimethyl-1-isoquinolinyl)- | [Molecular Formula]
C22H21NO4 | [MDL Number]
MFCD03661520 | [MOL File]
667427-75-0.mol | [Molecular Weight]
363.41 |
| Chemical Properties | Back Directory | [Boiling point ]
526.6±50.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
5.72±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+?concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals[1]. | [storage]
Store at -20°C | [References]
[1] S H?fner, et al. Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium. 2019 Mar;78:26-34. DOI:10.1016/j.ceca.2018.12.009 |
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